Cytotoxic diterpenoids from two lianas from the Suriname rainforest
Adou E; Williams R; Schilling J; Malone S; Meyer J; Wisse J; Frederik D; Koese D; Werkhoven M; Snipes C; Werk T; Kingston D
Bioorganic & Medicinal Chemistry
Bioassay-guided fractionation of the MeOH and EtOAc fractions of extracts of two lianas collected in Suriname has led to the isolation of five new diterpenoids humirianthone 1 1-hydroxy-humirianthone 2 15R-humirianthol 3 patagonol 4 and patagonal 5 and the five known diterpenoids humirianthol 7 annonalide 8 acrenol 9 icacinol 10 and the oxidized annonalide 11. All 10 diterpenoids showed cytotoxic activity against the A2780 human ovarian cancer cell line and compounds 1 3 8 and 9 also showed activity against phytopathogenic fungi.