India is endowed with a rich wealth of medicinal plants which are widely used by all sections of people either directly as folk medicines or indirectly in the pharmaceutical preparations. Among them climbing plants are one of the most interesting groups as apart from being medicinally important they form an important structural component and contribute major ecological role in forest dynamics diversity and nutrient recycling. Due to their multiple uses there is a need for creating genetically improved germplasm of climbers containing traits of disease resistance stress tolerance faster growth good adaptability improved performance and other value-added traits in particular. However conventional breeding programs are usually of low efficiency and time consuming for woody species because of their long juvenile period. Current status of the molecular approaches for integrative genetic transformation of highly medicinal climbers is reviewed.