The present ethnobotanical exploration study presents the folk medicinal uses of certain plants by tribes of the Sonbhadra district in the Uttar Pradesh state of India. One hundred and twenty five plants from 57 families which are therapeutically used against different diseases such as cough cold dysentery diarrhoea ulcers diabetes male and female weakness snake-bite and skin disorders are covered in this report. Part of the plant used dosage and the mode of drug administration in different ailments are described.