Ever since the commencement of human civilization plants have been used for multiple benefits viz. food medicines timber shelter and decorative purposes. Decreasing efficacy of modern medicine inclined the global market towards the herbal drugs providing plants as potent healers. Higher plants are the major source of many secondary metabolites useful in pharmaceutical industries. Commercial demand of secondary metabolites is increasing every day necessitating the exploitation of many endangered medicinal plants. In vitro propagation has the potential to quickly provide very high multiplication rate leading to conservation of endangered medicinal plants. It also enhances the production of desirable secondary metabolites from callus and suspension cultures throughout the years without any hindrance of external factors. The importance of ornamental plants has been increasing from the 1970s onwards and international demand has been rapidly expanding from aesthetic environment and economic point of view. The present review gives a consolidated account of in vitro protocols and secondary metabolite production of some endangered ornamental and medicinal climbers viz. Tinospora cordifolia Abrus precatorius Operculina turpethum Clitoria ternatea and Gymnema sylvestre.